Prof. Diehl’s most recent paper, “Chromatin as a key consumer in the metabolite economy”, was published today in Nature Chemical Biology. This perspective highlights emerging themes in the inter-regulation of the genome and metabolism via chromatin, including nonenzymatic histone modifications arising from chemically reactive metabolites, the expansion of PTM diversity from cofactor-promiscuous chromatin-modifying enzymes, and evidence for the existence and importance of subnucleocytoplasmic metabolite pools.
